Researchers using the CLF’s Octopus facility have discovered a new way of observing designer nanomaterials – materials that are 400 times smaller than a human hair.
The breakthrough has the potential to revolutionise the way nanomaterials are applied to medicine and catalytic chemical reactions, for example in designing ever smaller drug transporters.
The project involved researchers from the University of Bristol working with a team from the CLF’s Octopus microscopy facility. The research, recently published in the journal Science, explains how two-dimensional nanomaterials, called platelet micelles, can be identified using the super resolution imaging of the STFC’s microscope facility ‘Octopus’.
Platelet micelles consisting of three concentric rectangles, each incorporating fluorescent dyes of a different colour and with a central hole, can be easily seen in a fluorescence microscope. However, because the rectangles are about 200 nm thick, they appear blurred and overlapping.
“A conventional microscope cannot resolve multicolour objects on this scale but the structured illumination microscope within ‘Octopus’ is ideally suited to imaging objects between 100 and 300 nanometres in size. These discoveries are the first use of super-resolution techniques in this type of materials science research. The work opens the doors to being able to image a whole range of new materials that previously could not be observed effectively at high resolution” said Dr Stephen Webb, from Octopus.
The paper reports that these micelles have a highly controllable structure and are easily assembled into larger structures.
This, and the fact that they are easily functionalised, makes them a potential tool for a wider range of uses, including therapeutic applications and catalysis. For example, the circulation time of drug delivery vehicles in the body is dependent on their size and morphology. These features can becontrolled in these micelles and the platelets can also be functionalised to contain medically relevant molecules.
