Lin Wang

Senior Scientist/Professor

Professor Lin Wang is a Senior Scientist at Octopus. He obtained his PhD in Electrical and Electronic Engineering in 2010 from the University of Nottingham, under the supervision of Professor Mike Somekh FREng, during which time he developed a wide-field microscopic technique that obtained sub-100nm resolution by combining a solid immersion lens and structured illumination microscopy. Subsequently, he joined Professor Neil Hunter FRS’s research group at the University of Sheffield as a post-doctoral research fellow. In this role, Wang developed and applied various super-resolution microscopy and other functional biological imaging techniques to characterise the structure and function of biological photosynthetic membranes and light-harvesting protein complexes. In late 2015, Wang was appointed a permanent Staff Scientist at the CLF, and was promoted to Senior Scientist in 2020. Currently, he leads the user operation programme for super-resolution microscopy and develops innovative microscopy techniques for biological and medical imaging applications.

Professor Lin Wang’s research centres on advancing biomedical imaging technologies, with a particular emphasis on developing super-resolution microscopy techniques to overcome diffraction limitations. His pioneering work in solid immersion fluorescence microscopy has been particularly impactful, combining specialised lenses with super-resolution microscopy techniques to achieve unprecedented optical resolution. This work encompasses cryogenic microscopy and correlative imaging approaches, achieving notable resolution milestones such as 12nm imaging of cells using single-molecule localisation microscopy under cryogenic conditions. Wang’s collaborative research has significantly contributed to understanding biological structures and processes, including chromatin reorganisation in DNA damage responses, F-actin networks in Toxoplasma gondii, and myosin VI’s role in transcription initiation.

Wang, Lin, et al. “Solid immersion microscopy images cells under cryogenic conditions with 12 nm resolution.” Communications biology 2.1 (2019)
Dos Santos, Ália, et al. “DNA damage alters nuclear mechanics through chromatin reorganization.” Nucleic acids research 49.1 (2021)
Periz, Javier, et al. “A highly dynamic F-actin network regulates transport and recycling of micronemes in Toxoplasma gondii vacuoles.” Nature communications 10.1 (2019)