Selene’s research interests include using super-resolution fluorescence microscopy techniques to observe the responses of the Epidermal Growth Factor (EGF) family of Receptors to stimuli. She’s primarily interested in applying FLImP and MINFLUX techniques, combined with molecular dynamic simulations, to obtain a picture of the entire membrane-embedded EGF receptor. She’s interested in studying alternative receptor-receptor interactions that occur during aberrant signalling in cancerous cells and in cells expressing mutated receptors (naturally occurring and purposefully designed mutations). She’s also interested in perturbing cellular systems to identify the effects of therapeutically-relevant small molecule inhibitors and peptides on proliferation and survival signalling mechanisms.

 

 Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers​​

A small molecule inhibitor of HER3: a proof-of-concept study​

Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface