Professor Lin Wang’s research centres on advancing biomedical imaging technologies, with a particular emphasis on developing super-resolution microscopy techniques to overcome diffraction limitations. His pioneering work in solid immersion fluorescence microscopy has been particularly impactful, combining specialised lenses with super-resolution microscopy techniques to achieve unprecedented optical resolution. This work encompasses cryogenic microscopy and correlative imaging approaches, achieving notable resolution milestones such as 12nm imaging of cells using single-molecule localisation microscopy under cryogenic conditions. Wang’s collaborative research has significantly contributed to understanding biological structures and processes, including chromatin reorganisation in DNA damage responses, F-actin networks in Toxoplasma gondii, and myosin VI’s role in transcription initiation.
Selected publications
Solid immersion microscopy images cells under cryogenic conditions with 12 nm resolution
L Wang et al
DNA damage alters nuclear mechanics through chromatin reorganization
Ália Dos Santos et al
J Periz et al